Title | Transcription factor Egr-1 is required for long-term fear memory and anxiety. |
Publication Type | Journal Article |
Year of Publication | 2005 |
Authors | Ko SW, Ao H-S, Mendel AGallitano, Qiu C-S, Wei F, Milbrandt J, Zhuo M |
Journal | Sheng Li Xue Bao |
Volume | 57 |
Issue | 4 |
Pagination | 421-32 |
Date Published | 2005 Aug 25 |
ISSN | 0371-0874 |
Abstract | The zinc finger transcription factor Egr-1 is critical for coupling extracellular signals to changes in cellular gene expression. In the hippocampus and amygdala, two major central regions for memory formation and storage, Egr-1 is up-regulated by long-term potentiation (LTP) and learning paradigms. Using Egr-1 knockout mice, we showed that Egr-1 was selectively required for late auditory fear memory while short term, trace and contextual memory were not affected. Additionally, synaptic potentiation induced by theta burst stimulation in the amygdala and auditory cortex was significantly reduced or blocked in Egr-1 knockout mice. Our study suggests that the transcription factor Egr-1 plays a selective role in late auditory fear memory. |
Alternate Journal | Sheng Li Xue Bao |
PubMed ID | 16094488 |